Galectin-3 immunostaining in thyroid neoplasms
نویسنده
چکیده
1. Medical doctor; resident on Pathology, Hospital de Base do Distrito Federal (HBDF). 2. Chairman professor of Pathology, PhD in Pathology, Department of Pathology, Universidade de Brasília (UnB). Work developed at the Laboratory of Pathology, Faculty of Medicine, Universidade de Brasília, and supported by Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Fundação de Empreendimentos Científicos e Tecnológicos (FINATEC) and Programa Institucional de Bolsas de Iniciação Científica (PIBIC/UnB). J Bras Patol Med Lab • v. 41 • n. 5 • p. 341-46 • outubro 2005
منابع مشابه
Intensity and distribution of immunohistochemical expression of galectin-3 in thyroid neoplasms.
The aim of the study was to assess the intensity and distribution of galectin-3 expression in benign and malignant thyroid neoplasms by immunohistochemical method. Immunohistochemical expression of galectin-3 was analyzed in surgical thyroid specimens from 82 patients with histopathologic diagnosis of follicular adenoma (n = 32), Hürthle cell adenoma (n = 10) and papillary carcinoma (n = 40). R...
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AIMS To investigate the usefulness of immunohistochemical expression and immunolocalization of a panel of thyroid malignancy markers including HBME-1, cytokeratin (CK) 19 and galectin-3. METHODS AND RESULTS We evaluated 170 thyroid lesions including 148 neoplastic lesions [84 papillary carcinomas (PC), 38 follicular carcinomas (FC), 18 follicular adenomas, one hyalinizing trabecular tumour, f...
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Indeterminate thyroid nodules form a heterogenous group of lesions that constitute 5% to 30% of thyroid cytology diagnoses. We introduce a triple immunostaining protocol for subtyping. Galectin-3, HBME-1, and p27 triple immunostaining, performed on destained cytology slides and formalin-fixed paraffin-embedded tissue, was developed and applied to 51 patients retrospectively with preoperative cy...
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Background The aim of this study is to investigate the role of Galectin-3 in human thyroid cancer migration. Methods The expression of Galectin-3 in surgical specimens was investigated using immunohistochemistry and western blot. A papillary thyroid cancer cell line (B-cpap) and an anaplastic thyroid cancer cell line (8305c) were transfected with short-hairpin RNA against Galectin-3 (Gal-3-sh...
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